Pubblicazioni

Autori:

Marangi, Antonio; Gajofatto, Alberto; Marastoni, Damiano; Gobbin, Francesca; Guiotto, Flavio; Tonin, Paola; Benedetti, Maria Donata

Titolo:

A case of multiple sclerosis and necrotizing autoimmune myopathy with anti-SRP antibodies

Anno:

2018

Tipologia prodotto:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Lingua:

Inglese

Formato:

A Stampa

Referee:

Sì

Nome rivista:

MULTIPLE SCLEROSIS AND RELATED DISORDERS

ISSN Rivista:

2211-0348

N° Volume:

19

Intervallo pagine:

118-120

Parole chiave:

Anti-SRP; Multiple sclerosis; Necrotizing myopathy

Breve descrizione dei contenuti:

Only few reports exist regarding the coexistence of multiple sclerosis (MS) and autoimmune myopathies. We describe the case of a man with a long history of undiagnosed left lower limb motor impairment who was hospitalized for subacute onset of a myopathic syndrome. In addition, neurological examination revealed sensory impairment and pyramidal signs in the left limbs. Muscle biopsy revealed a necrotizing myopathy and serum anti-signal recognition particle (SRP) antibodies were found. Brain and spinal cord MRI displayed several non-enhancing demyelinating lesions, and CSF-restricted oligoclonal bands were detected. Multimodal evoked potentials showed increased latency of central conduction. Total body PET-CT did not reveal malignancies. A final diagnosis of anti-SRP necrotizing autoimmune myopathy (NAM) and MS was made, and subsequent therapy with azathioprine resulted in a complete stability for both diseases during the follow up. To the best of our knowledge this is the first reported case of concomitant NAM and MS.

Pagina Web:

https://doi.org/10.1016/j.msard.2017.11.015

Id prodotto:

99586

Handle IRIS:

11562/970905

ultima modifica:

11 novembre 2022

Citazione bibliografica:

Marangi, Antonio; Gajofatto, Alberto; Marastoni, Damiano; Gobbin, Francesca; Guiotto, Flavio; Tonin, Paola; Benedetti, Maria Donata, A case of multiple sclerosis and necrotizing autoimmune myopathy with anti-SRP antibodies «MULTIPLE SCLEROSIS AND RELATED DISORDERS» , vol. 19 , 2018 , pp. 118-120

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