Pubblicazioni

Autori:

Versace, Viviana; Langthaler, Patrick B; Höller, Yvonne; Frey, Vanessa N; Brigo, Francesco; Sebastianelli, Luca; Saltuari, Leopold; Nardone, Raffaele

Titolo:

Abnormal cortical neuroplasticity induced by paired associative stimulation after traumatic spinal cord injury: a preliminary study

Anno:

2018

Tipologia prodotto:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Lingua:

Inglese

Formato:

A Stampa

Referee:

Sì

Nome rivista:

Neuroscience Letters

ISSN Rivista:

0304-3940

N° Volume:

664

Intervallo pagine:

167-171

Parole chiave:

Transcranial magnetic stimulation; paired associative stimulation; spinal cord injury; synaptic plasticity

Breve descrizione dei contenuti:

We aimed at assessing in this pilot study whether patients with spinal cord injury (SCI) show alterations of sensorimotor plasticity within the primary motor cortex (M1). Since learning in human M1 occurs through LTP-like mechanisms, we employed the paired associative stimulation (PAS) protocol by transcranial magnetic stimulation (TMS), which is able to induce LTP-like effects in M1, in subjects with chronic SCI. We found that PAS protocol significantly increased corticospinal excitability as long as 30minutes in healthy subjects and in SCI patients with good motor recovery, while it was followed by a non-significant increase of MEP amplitude in the SCI patients with poor functional recovery. These findings suggest that the level of LTP-like phenomena is correlated with long term recovery and support the correlation between the ability of inducing excitability changes using TMS and the process of motor recovery. Increased cortical plasticity might imply greater capability for neuromodulation.

Pagina Web:

https://doi.org/10.1016/j.neulet.2017.11.003

Id prodotto:

99863

Handle IRIS:

11562/971713

ultima modifica:

15 novembre 2022

Citazione bibliografica:

Versace, Viviana; Langthaler, Patrick B; Höller, Yvonne; Frey, Vanessa N; Brigo, Francesco; Sebastianelli, Luca; Saltuari, Leopold; Nardone, Raffaele, Abnormal cortical neuroplasticity induced by paired associative stimulation after traumatic spinal cord injury: a preliminary study «Neuroscience Letters» , vol. 664 , 2018 , pp. 167-171

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