Pubblicazioni

Long-Acting GLP-1 Receptor Agonist Exenatide Influence on the Autonomic Cardiac Sympatho-Vagal Balance  (2017)

Autori:
Cacciatori, Vittorio; Zoppini, Giacomo; Bellavere, Federico; Rigolon, Riccardo; Thomaseth, Karl; Pichiri, Isabella; Trombetta, Maddalena; Dauriz, Marco; De Santi, Francesca; Targher, Giovanni; Santi, Lorenza; Bonora, Enzo
Titolo:
Long-Acting GLP-1 Receptor Agonist Exenatide Influence on the Autonomic Cardiac Sympatho-Vagal Balance
Anno:
2017
Tipologia prodotto:
Articolo in Rivista
Tipologia ANVUR:
Articolo su rivista
Lingua:
Inglese
Formato:
Elettronico
Referee:
Nome rivista:
JOURNAL OF THE ENDOCRINE SOCIETY
ISSN Rivista:
2472-1972
N° Volume:
2
Numero o Fascicolo:
1
Intervallo pagine:
53-62
Parole chiave:
autonomic nervous system, GLP-1 receptor agonist, power spectral analysis
Breve descrizione dei contenuti:
Long-acting glucagon-like peptide 1 receptor agonists are increasingly used to treat type 2 diabetes. An increase of heart rate (HR) has been observed with their use. To elucidate the role of the cardiac sympatho-vagal balance as a possible mediator of the reported increase in HR, we performed power spectral analysis of HR variability (HRV) in patients receiving exenatide extended-release (ER). Twenty-eight ambulatory patients with type 2 diabetes underwent evaluation at initiation of exenatide-ER and thereafter at 3 and at 6 months. To obtain spectral analyses of HRV, a computerized acquisition of 10 minutes of RR electrocardiogram intervals (mean values of ~700 RR intervals) were recorded both in lying and in standing positions. All patients showed a substantial increase of HR both in lying and in standing positions. Systolic blood pressure, body weight, and glycated hemoglobin A1c significantly decreased both at 3 and 6 months compared with basal levels. The low-frequency/high-frequency ratio varied from 3.05 ± 0.4 to 1.64 ± 0.2 (P < 0.001) after 3 months and to 1.57 ± 0.3 (P < 0.001) after 6 months in a lying position and from 4.56 ± 0.8 to 2.24 ± 0.3 (P < 0.001) after 3 months and to 2.38 ± 0.4 (P < 0.001) after 6 months in a standing position compared with basal values, respectively. HR variations, induced by exenatide-ER treatment, do not appear to be related to sympathetic autonomic tone. Of note, we observed a relative increase of vagal influence on the heart.
Id prodotto:
99927
Handle IRIS:
11562/971858
ultima modifica:
15 novembre 2022
Citazione bibliografica:
Cacciatori, Vittorio; Zoppini, Giacomo; Bellavere, Federico; Rigolon, Riccardo; Thomaseth, Karl; Pichiri, Isabella; Trombetta, Maddalena; Dauriz, Marco; De Santi, Francesca; Targher, Giovanni; Santi, Lorenza; Bonora, Enzo, Long-Acting GLP-1 Receptor Agonist Exenatide Influence on the Autonomic Cardiac Sympatho-Vagal Balance «JOURNAL OF THE ENDOCRINE SOCIETY» , vol. 2 , n. 12017pp. 53-62

Consulta la scheda completa presente nel repository istituzionale della Ricerca di Ateneo IRIS

<<indietro

Attività

Strutture

Condividi