Pubblicazioni

Autori:

Targher, Giovanni; Lonardo, Amedeo; Byrne, Christopher D.

Titolo:

Nonalcoholic fatty liver disease and chronic vascular complications of diabetes mellitus

Anno:

2018

Tipologia prodotto:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Lingua:

Inglese

Formato:

A Stampa

Referee:

Sì

Nome rivista:

NATURE REVIEWS. ENDOCRINOLOGY

ISSN Rivista:

1759-5029

N° Volume:

14

Numero o Fascicolo:

2

Intervallo pagine:

99-114

Parole chiave:

NAFLD, diabetes, vascular complications, review

Breve descrizione dei contenuti:

Nonalcoholic fatty liver disease (NAFLD) and diabetes mellitus are common diseases that often coexist and might act synergistically to increase the risk of hepatic and extra-hepatic clinical outcomes. NAFLD affects up to 70-80% of patients with type 2 diabetes mellitus and up to 30-40% of adults with type 1 diabetes mellitus. The coexistence of NAFLD and diabetes mellitus increases the risk of developing not only the more severe forms of NAFLD but also chronic vascular complications of diabetes mellitus. Indeed, substantial evidence links NAFLD with an increased risk of developing cardiovascular disease and other cardiac and arrhythmic complications in patients with type 1 diabetes mellitus or type 2 diabetes mellitus. NAFLD is also associated with an increased risk of developing microvascular diabetic complications, especially chronic kidney disease. This Review focuses on the strong association between NAFLD and the risk of chronic vascular complications in patients with type 1 diabetes mellitus or type 2 diabetes mellitus, thereby promoting an increased awareness of the extra-hepatic implications of this increasingly prevalent and burdensome liver disease. We also discuss the putative underlying mechanisms by which NAFLD contributes to vascular diseases, as well as the emerging role of changes in the gut microbiota (dysbiosis) in the pathogenesis of NAFLD and associated vascular diseases.

Id prodotto:

100046

Handle IRIS:

11562/972114

ultima modifica:

12 novembre 2022

Citazione bibliografica:

Targher, Giovanni; Lonardo, Amedeo; Byrne, Christopher D., Nonalcoholic fatty liver disease and chronic vascular complications of diabetes mellitus «NATURE REVIEWS. ENDOCRINOLOGY» , vol. 14 , n. 2 , 2018 , pp. 99-114

Consulta la scheda completa presente nel repository istituzionale della Ricerca di Ateneo