Publications

Authors:

Zarantonello, Diana; Barbara Piccoli, Giorgina; Zuccarello, Daniela; Tescaro, Mauro; Mariani, Ilaria; Luehwink, Arne; Brunori, Giuliano

Title:

ADPKD, pregnancy and preimplantation selection: clinical and bioethical considerations

Year:

2026

Type of item:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Language:

Inglese

Format:

Elettronico

Referee:

Sì

Name of journal:

Journal of Nephrology

Page numbers:

1-13

Keyword:

Medically assisted reproductive technologies; Preimplantation genetic diagnosis; Reproductive decision-making

Short description of contents:

Preimplantation genetic diagnosis for monogenic disorders makes it possible to identify and select embryos free of specific genetic mutations prior to uterine transfer, using embryos produced via medically assisted reproductive technologies. Since 2015, the Italian legal system has allowed parents who are carriers of, or affected by, monogenic hereditary conditions, including autosomal dominant polycystic kidney disease (ADPKD), to access preimplantation genetic diagnosis. However, the experience remains limited, and its application in particular to a late onset disease like ADPKD raises clinical and ethical concerns. These include the potential health risks associated with assisted reproductive technologies for the woman, the risk of assisted reproductive technology failure, moral permissibility of embryo selection, psychosocial implications for the couple and child, and issues related to equitable access to these treatments. An effective preconception counseling strategy should be grounded in a shared decision-making framework involving the prospective parents and a multidisciplinary medical team, including specialists in nephrology, obstetrics, and human genetics. This review aims to discuss the principal bioethical considerations surrounding preimplantation genetic diagnosis for ADPKD, in order to support clinicians involved in genetic counseling and reproductive decision-making.

Web page:

https://academic.oup.com/joneph/advance-article/doi/10.1093/joneph/aajag051/8687588

Product ID:

151992

Handle IRIS:

11562/1197048

Last Modified:

July 2, 2026

Bibliographic citation:

Zarantonello, Diana; Barbara Piccoli, Giorgina; Zuccarello, Daniela; Tescaro, Mauro; Mariani, Ilaria; Luehwink, Arne; Brunori, Giuliano, ADPKD, pregnancy and preimplantation selection: clinical and bioethical considerations «Journal of Nephrology » , 2026 , pp. 1-13

Consulta la scheda completa presente nel repository istituzionale della Ricerca di Ateneo