- Authors:
-
Targher, Giovanni; Lonardo, Amedeo; Byrne, Christopher D.
- Title:
-
Nonalcoholic fatty liver disease and chronic vascular complications of diabetes mellitus
- Year:
-
2018
- Type of item:
-
Articolo in Rivista
- Tipologia ANVUR:
- Articolo su rivista
- Language:
-
Inglese
- Format:
-
A Stampa
- Referee:
-
Sì
- Name of journal:
- NATURE REVIEWS. ENDOCRINOLOGY
- ISSN of journal:
- 1759-5029
- N° Volume:
-
14
- Number or Folder:
-
2
- Page numbers:
-
99-114
- Keyword:
-
NAFLD, diabetes, vascular complications, review
- Short description of contents:
- Nonalcoholic fatty liver disease (NAFLD) and diabetes mellitus are common diseases that often coexist and might act synergistically to increase the risk of hepatic and extra-hepatic clinical outcomes. NAFLD affects up to 70-80% of patients with type 2 diabetes mellitus and up to 30-40% of adults with type 1 diabetes mellitus. The coexistence of NAFLD and diabetes mellitus increases the risk of developing not only the more severe forms of NAFLD but also chronic vascular complications of diabetes mellitus. Indeed, substantial evidence links NAFLD with an increased risk of developing cardiovascular disease and other cardiac and arrhythmic complications in patients with type 1 diabetes mellitus or type 2 diabetes mellitus. NAFLD is also associated with an increased risk of developing microvascular diabetic complications, especially chronic kidney disease. This Review focuses on the strong association between NAFLD and the risk of chronic vascular complications in patients with type 1 diabetes mellitus or type 2 diabetes mellitus, thereby promoting an increased awareness of the extra-hepatic implications of this increasingly prevalent and burdensome liver disease. We also discuss the putative underlying mechanisms by which NAFLD contributes to vascular diseases, as well as the emerging role of changes in the gut microbiota (dysbiosis) in the pathogenesis of NAFLD and associated vascular diseases.
- Product ID:
-
100046
- Handle IRIS:
-
11562/972114
- Last Modified:
-
November 12, 2022
- Bibliographic citation:
-
Targher, Giovanni; Lonardo, Amedeo; Byrne, Christopher D.,
Nonalcoholic fatty liver disease and chronic vascular complications of diabetes mellitus
«NATURE REVIEWS. ENDOCRINOLOGY»
, vol.
14
, n.
2
,
2018
,
pp. 99-114
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