Publications

Authors:

Bontempi, Pietro; Busato, Alice; Bonafede, Roberta; Schiaffino, Lorenzo; Scambi, Ilaria; Sbarbati, Andrea; Mariotti, Raffaella; Marzola, Pasquina

Title:

MRI reveals therapeutical efficacy of stem cells: an experimental study on the SOD1(G93A) animal model

Year:

2018

Type of item:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Language:

Inglese

Format:

A Stampa

Referee:

Sì

Name of journal:

Magnetic Resonance in Medicine

ISSN of journal:

0740-3194

N° Volume:

79

Number or Folder:

1

Page numbers:

459-469

Keyword:

MRI; SOD1(G93A); amyotrophic lateral sclerosis; mesenchymal stem cells; voxel-based morphometry

Short description of contents:

PURPOSE: The first part of the experiment identifies and validates MRI biomarkers distinctive of the disease progression in the transgenic superoxide dismutase gene (SOD1(G93A)) animal model. The second part assesses the efficacy of a mesenchymal stem cell-based therapy through the MRI biomarkers previously defined. METHODS: The first part identifies MRI differences between SOD1(G93A) and healthy mice. The second part of the experiment follows the disease evolution of stem cell-treated and non-stem-cell treated SOD1(G93A) mice. The analysis focused on voxel-based morphometry and T2 mapping on the brain tissues, and T2-weighted imaging and diffusion tensor imaging (DTI) on the hind limbs. RESULTS: Comparing diseased mice to healthy control revealed gray matter alterations in the brainstem area, accompanied by increased T2 relaxation time. Differences in muscle volume, muscle signal intensity, fractional anisotropy, axial diffusivity, and radial diffusivity were measured in the hind limbs. In the comparison between stem cell-treated mice and nontreated ones, differences in muscle volume, muscle signal intensity, and DTI-derived maps were found. CONCLUSION: MRI-derived biomarkers can be used to identify differences between stem cell-treated and nontreated SOD1(G93A) mice. Magn Reson Med, 2017. © 2017 International Society for Magnetic Resonance in Medicine.

Web page:

https://doi.org/10.1002/mrm.26685

Product ID:

97627

Handle IRIS:

11562/963159

Last Modified:

December 2, 2022

Bibliographic citation:

Bontempi, Pietro; Busato, Alice; Bonafede, Roberta; Schiaffino, Lorenzo; Scambi, Ilaria; Sbarbati, Andrea; Mariotti, Raffaella; Marzola, Pasquina, MRI reveals therapeutical efficacy of stem cells: an experimental study on the SOD1(G93A) animal model «Magnetic Resonance in Medicine» , vol. 79 , n. 1 , 2018 , pp. 459-469

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