Pubblicazioni

Autori:

Bontempi, Pietro; Busato, Alice; Bonafede, Roberta; Schiaffino, Lorenzo; Scambi, Ilaria; Sbarbati, Andrea; Mariotti, Raffaella; Marzola, Pasquina

Titolo:

MRI reveals therapeutical efficacy of stem cells: an experimental study on the SOD1(G93A) animal model

Anno:

2018

Tipologia prodotto:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Lingua:

Inglese

Formato:

A Stampa

Referee:

Sì

Nome rivista:

Magnetic Resonance in Medicine

ISSN Rivista:

0740-3194

N° Volume:

79

Numero o Fascicolo:

1

Intervallo pagine:

459-469

Parole chiave:

MRI; SOD1(G93A); amyotrophic lateral sclerosis; mesenchymal stem cells; voxel-based morphometry

Breve descrizione dei contenuti:

PURPOSE: The first part of the experiment identifies and validates MRI biomarkers distinctive of the disease progression in the transgenic superoxide dismutase gene (SOD1(G93A)) animal model. The second part assesses the efficacy of a mesenchymal stem cell-based therapy through the MRI biomarkers previously defined. METHODS: The first part identifies MRI differences between SOD1(G93A) and healthy mice. The second part of the experiment follows the disease evolution of stem cell-treated and non-stem-cell treated SOD1(G93A) mice. The analysis focused on voxel-based morphometry and T2 mapping on the brain tissues, and T2-weighted imaging and diffusion tensor imaging (DTI) on the hind limbs. RESULTS: Comparing diseased mice to healthy control revealed gray matter alterations in the brainstem area, accompanied by increased T2 relaxation time. Differences in muscle volume, muscle signal intensity, fractional anisotropy, axial diffusivity, and radial diffusivity were measured in the hind limbs. In the comparison between stem cell-treated mice and nontreated ones, differences in muscle volume, muscle signal intensity, and DTI-derived maps were found. CONCLUSION: MRI-derived biomarkers can be used to identify differences between stem cell-treated and nontreated SOD1(G93A) mice. Magn Reson Med, 2017. © 2017 International Society for Magnetic Resonance in Medicine.

Pagina Web:

https://doi.org/10.1002/mrm.26685

Id prodotto:

97627

Handle IRIS:

11562/963159

ultima modifica:

2 dicembre 2022

Citazione bibliografica:

Bontempi, Pietro; Busato, Alice; Bonafede, Roberta; Schiaffino, Lorenzo; Scambi, Ilaria; Sbarbati, Andrea; Mariotti, Raffaella; Marzola, Pasquina, MRI reveals therapeutical efficacy of stem cells: an experimental study on the SOD1(G93A) animal model «Magnetic Resonance in Medicine» , vol. 79 , n. 1 , 2018 , pp. 459-469

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