Pubblicazioni

Autori:

Santangelo, Alessandra; Imbruce', Pietro; Gardenghi, Beatrice; Belli, Laura; Agushi, Rina; Tamanini, Anna; Munari, Silvia; Bossi, Alessandra Maria; Scambi, Ilaria; Benati, Donatella; Mariotti, Raffaella; DI GENNARO, Gianfranco; Sbarbati, Andrea; Eccher, Albino; Ricciardi, GIUSEPPE KENNETH; Ciceri, Elisa Maria; Sala, Francesco; Pinna, Giampietro; Lippi, Giuseppe; Cabrini, Giulio; Dechecchi, Maria Cristina

Titolo:

A microRNA signature from serum exosomes of patients with glioma as complementary diagnostic biomarker

Anno:

2018

Tipologia prodotto:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Lingua:

Inglese

Formato:

A Stampa

Referee:

Sì

Nome rivista:

Journal of Neuro Oncology

ISSN Rivista:

0167-594X

N° Volume:

136

Numero o Fascicolo:

1

Intervallo pagine:

51-62

Parole chiave:

Circulating biomarkers; Exosomes; Gliomas; MiRNAs

Breve descrizione dei contenuti:

Malignant gliomas, the most frequent primary brain tumors, are characterized by a dismal prognosis. Reliable biomarkers complementary to neuroradiology in the differential diagnosis of gliomas and monitoring for post-surgical progression are unmet needs. Altered expression of several microRNAs in tumour tissues from patients with gliomas compared to normal brain tissue have been described, thus supporting the rationale of using microRNA-based biomarkers. Although different circulating microRNAs were proposed in association with gliomas, they have not been introduced into clinical practice so far. Blood samples were collected from patients with high and low grade gliomas, both before and after surgical resection, and the expression of miR-21, miR-222 and miR-124-3p was measured in exosomes isolated from serum. The expression levels of miR-21, miR-222 and miR-124-3p in serum exosomes of patients with high grade gliomas were significantly higher than those of low grade gliomas and healthy controls and were sharply decreased in samples obtained after surgery. The analysis of miR-21, miR-222 and miR-124-3p in serum exosomes of patients affected by gliomas can provide a minimally invasive and innovative tool to help the differential diagnosis of gliomas at their onset in the brain and predict glioma grading and non glial metastases before surgery.

Pagina Web:

https://doi.org/10.1007/s11060-017-2639-x

Id prodotto:

99941

Handle IRIS:

11562/971961

ultima modifica:

26 novembre 2022

Citazione bibliografica:

Santangelo, Alessandra; Imbruce', Pietro; Gardenghi, Beatrice; Belli, Laura; Agushi, Rina; Tamanini, Anna; Munari, Silvia; Bossi, Alessandra Maria; Scambi, Ilaria; Benati, Donatella; Mariotti, Raffaella; DI GENNARO, Gianfranco; Sbarbati, Andrea; Eccher, Albino; Ricciardi, GIUSEPPE KENNETH; Ciceri, Elisa Maria; Sala, Francesco; Pinna, Giampietro; Lippi, Giuseppe; Cabrini, Giulio; Dechecchi, Maria Cristina, A microRNA signature from serum exosomes of patients with glioma as complementary diagnostic biomarker «Journal of Neuro Oncology» , vol. 136 , n. 1 , 2018 , pp. 51-62

Consulta la scheda completa presente nel repository istituzionale della Ricerca di Ateneo