Publications

Authors:

Prunas, Cecilia; Delvecchio, Giuseppe; Perlini, Cinzia; Barillari, Marco; Ruggeri, Mirella; Altamura, A. Carlo; Bellani, Marcella; Brambilla, Paolo

Title:

Diffusion imaging study of the Corpus Callosum in bipolar disorder

Year:

2018

Type of item:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Language:

Inglese

Format:

A Stampa

Referee:

Sì

Name of journal:

PSYCHIATRY RESEARCH-NEUROIMAGING

ISSN of journal:

0925-4927

N° Volume:

271

Page numbers:

75-81

Keyword:

bipolar disorder; corpus callosum; diffusion-weighted imaging; Magnetic Resonance Imaging

Short description of contents:

Structural and diffusion imaging studies have provided some evidence of abnormal organization of Corpus Callosum (CC) in Bipolar Disorder (BD). Therefore, by using Diffusion Weighted Imaging (DWI), which allows to build subtle prediction models of fiber integrity for white matter (WM) tracts, this study aims to further explore the microstructure integrity of CC in BD patients compared to matched healthy controls. Twenty-four chronic patients with BD and 35 healthy controls were included in the study. Circular regions of interest were placed, on diffusion images, in the left and right side of callosal regions (i.e. rostrum/genu, anterior body, posterior body, splenium) and the Apparent Diffusion Coefficient (ADC) was then calculated. Significantly increased ADC values were found in right anterior body and in right splenium in BD patients compared to healthy controls (all p < 0.05, Bonferroni corrected). In this study, we found abnormally increased ADC callosal values in BD suggesting microstructural anomalies specifically in the right hemisphere. Interestingly, this finding further supports the presence of an altered inter-hemispheric communication between frontal and temporo-parietal association areas in patients with BD, which may ultimately result in clinical symptoms and cognitive deficits.

Web page:

https://doi.org/10.1016/j.pscychresns.2017.11.001

Product ID:

99865

Handle IRIS:

11562/971711

Last Modified:

November 18, 2022

Bibliographic citation:

Prunas, Cecilia; Delvecchio, Giuseppe; Perlini, Cinzia; Barillari, Marco; Ruggeri, Mirella; Altamura, A. Carlo; Bellani, Marcella; Brambilla, Paolo, Diffusion imaging study of the Corpus Callosum in bipolar disorder «PSYCHIATRY RESEARCH-NEUROIMAGING» , vol. 271 , 2018 , pp. 75-81

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