Publications

Authors:

Fabrizi, Gian Maria; Tamburin, Stefano; Cavallaro, Tiziana; Cabrini, Ilaria; Ferrarini, Moreno; Taioli, Federica; Magrinelli, Francesca; Zanette, Giampietro

Title:

The spectrum of Charcot-Marie-Tooth disease due to myelin protein zero: An electrodiagnostic, nerve ultrasound and histological study

Year:

2018

Type of item:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Language:

Inglese

Format:

A Stampa

Referee:

Sì

Name of journal:

Clinical Neurophysiology

ISSN of journal:

1388-2457

N° Volume:

129

Number or Folder:

1

Page numbers:

21-32

Keyword:

electrodiagnostic study; genetics; myelin protein zero (MPZ); nerve biopsy; nerve ultrasound; stratification

Short description of contents:

Objective: Nerve ultrasound (US) data on myelin protein zero (MPZ)-related Charcot-Marie-Tooth disease (CMT) are lacking. To offer a comprehensive perspective on MPZ-related CMTs, we combined nerve US with clinics, electrodiagnosis and histopathology. Methods We recruited 36 patients (12 MPZ mutations), and correlated nerve US to clinical, electrodiagnostic measures, and sural nerve biopsy. Results According to motor nerve conduction velocity (MNCV) criteria, nine patients were categorized as “demyelinating” CMT1B, 17 as “axonal” CMT2I/J, and 10 as dominant “intermediate” CMTDID. Sural nerve biopsy showed hypertrophic de-remyelinating neuropathy with numerous complex onion bulbs in one patient, de-remyelinating neuropathy with scanty/absent onion bulbs in three, axonal neuropathy in two, mixed demyelinating-axonal neuropathy in five. Electrodiagnosis significantly differed in CMT1B vs. CMT2I/J and CMTDID subgroups. CMT1B had slightly enlarged nerve cross sectional area (CSA) especially at proximal upper-limb (UL) sites. CSA was negatively correlated to UL MNCV and not increased at entrapment sites. Major sural nerve pathological patterns were uncorrelated to UL nerve US and MNCV. Conclusions Sural nerve biopsy confirmed the wide pathological spectrum of MPZ-CMT. UL nerve US identified two major patterns corresponding to the CMT1B and CMT2I/J-CMTDID subgroups. Significance Nerve US phenotype of MPZ-CMT diverged from those in other demyelinating peripheral neuropathies and may have diagnostic value. © 2017 International Federation of Clinical Neurophysiology

Web page:

https://doi.org/10.1016/j.clinph.2017.09.117

Product ID:

99860

Handle IRIS:

11562/971724

Last Modified:

November 15, 2022

Bibliographic citation:

Fabrizi, Gian Maria; Tamburin, Stefano; Cavallaro, Tiziana; Cabrini, Ilaria; Ferrarini, Moreno; Taioli, Federica; Magrinelli, Francesca; Zanette, Giampietro, The spectrum of Charcot-Marie-Tooth disease due to myelin protein zero: An electrodiagnostic, nerve ultrasound and histological study «Clinical Neurophysiology» , vol. 129 , n. 1 , 2018 , pp. 21-32

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